People

David R. Raleigh, MD, PhD

Assistant Professor

Principal Investigator and Preclinical Therapeutics Core Director

Brain Tumor Center

Departments of Radiation Oncology and Neurological Surgery

University of California San Francisco

Dr. David Raleigh is an expert in the treatment and investigation of brain tumors. He received his undergraduate degree from the University of California Berkeley, and his medical and doctoral degrees from the University of Chicago. Dr. Raleigh completed his residency training in Radiation Oncology at UCSF, and he trained as a postdoctoral scholar with Dr. Jeremy Reiter in the Department of Biochemistry at UCSF, with whom he continues to collaborate closely. He is a member of the faculty in the UCSF Departments of Radiation Oncology and Neurological Surgery where he is specialized in the treatment and investigation of central nervous system tumors in adult and pediatric patients. In the laboratory, Dr. Raleigh is a Principal Investigator in the UCSF Brain Tumor Center and uses mouse genetics, genomics, cell biology, biochemistry, molecular biology and pharmacology to study developmental pathways in cancer and identify novel targets for molecular therapy and patient stratification. Dr. Raleigh is also the director of the UCSF Brain Tumor Center Preclinical Core, a longstanding facility within the Department of Neurological Surgery with extensive expertise in patient-derived xenograph mouse models of brain cancer.

Lab social event at St. George Spirits (Summer 2018)

Current Lab Members

Abrar is an MD/PhD student in the Biomedical Sciences program at UCSF. His background is in epigenetic regulation of oncogenic drivers of breast cancer. In the Raleigh lab, he is a gradute student studying the Hedgehog pathway in a variety of cancers, and working to identify biomarkers to better understand the biology and prognosis of cancer.

Vikas is an MD/PhD student in the Biomedical Sciences program at UCSF. As a graduate student in the Raleigh lab, he is studying combination molecular therapy for the treatment of Hedgehog-associated medulloblastoma, in addition to exploring oxysterol-mediated signaling in the Hedgehog pathway. His background is in centrosome biology, where he utilized genome-wide CRISPR screens to identify the molecular components of a novel cell cycle arrest following centrosome duplication failure. In the rare moments not in the lab, Vikas loves running, cooking (if you're nice to him you may get a fancy dinner) and traveling

Sarah is an Assistant Specialist in the Department of Radiation Oncology and she is the Lab Manager of the Raleigh Lab. She received her Engineer diploma in SupBiotech Paris, France. She is specialized in cellular and molecular biology, and she works on synthesis and trafficking of Smoothened-activating oxysterols.

Sydney is a Staff Research Associate in the Departments of Radiation Oncology and Neurological Surgery. She received her undergraduate degree in biology from Reed College, where she focused on development and genetics. In the Raleigh Lab she participates in various research projects, and also helps to maintain the laboratory mouse colony. She is very excited to be helping her teammates explore the ways in which the developmental signaling pathways in cancer. In her free time Sydney likes to play music, and tries to stay involved in the San Francisco and Oakland music scenes. She also enjoys hiking, photography and hanging out with her dog, Sunny.

Stephen is a Resident Physician in the Department of Neurological Surgery. His background is in cellular and molecular neuroscience and gene regulation. His clinical research is focused on outcomes for meningioma patients. He is currently an NIH-funded post-doc in the Raleigh and Costello labs and is leveraging his access to clinical samples and outcomes data in concert with genome wide approaches to identify molecular drivers of meningioma growth and recurrence. In his free time, Stephen enjoys spending time with his wife, sailing, tasting wine and exploring California's natural beauty.

Harish is a resident physician in the Department of Radiation Oncology at UCSF. He received his MD and PhD degrees at the Mount Sinai School of Medicine, where his dissertation focused on developmental biology and receptor tyrosine kinase signaling. He is interested in combining genomic approaches with molecular biology techniques to understand cellular decision making. In the Raleigh lab, Harish uses multiplatform bioinformatic techniques to explore the mechanisms underlying brain tumor growth.